![]() The vehicle usually contains water, oil, alcohol or propylene glycol mixed with emulsifiers, promoters for absorption, preservatives, and fragrances. Topical products are formulated in a base or “vehicle” which may be optimized for a particular type of skin condition or site on the body. ![]() Depending upon their oil content, different forms can be more or less desirable for treating diseases such as dry skin, rashes, or skin lesions as the drug product stays on the skin surface to protect against moisture loss. Each form can serve a different purpose due to the API and excipients as well as the ratios of oil and water. Choosing the right form for topical delivery of a drug can be challenging. There are reduced side effects and toxicity to other organs as a result of this type of delivery compared to systemically delivered medications (oral, injectable, etc.). ![]() The ChallengesĪs discussed earlier, there has been an increase in the development of topical drug products as a way to deliver drugs locally to those surfaces, rather than systemically. In part two of these blog posts, we will discuss the various types of topical products (ointments, creams, gels, sprays, and lotions), detailing their characteristics both in terms of formulation and use.
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